Early Prone Positioning Monitored by Electrical Impedance Tomography in Patients With Acute Respiratory Distress Syndrome

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Acute Respiratory Distress Syndrome (ARDS) is a syndrome characterized by respiratory distress and refractory hypoxemia caused by pulmonary and extra-pulmonary factors. Despite improvements in diagnosis and treatment in recent years, the mortality rate of severe ARDS is still around 40%. The distribution of lung lesions in ARDS patients is significantly gravity-dependent. Even with lung-protective ventilation strategies, tidal volume is concentrated in the ventral lung region, leading to ventilator-associated lung injury. Prone position ventilation can increase ventilation to the dorsal lung tissue and improve the ventilation-perfusion ratio, thus improving oxygenation. During prone position ventilation in ARDS patients, lung-protective ventilation strategies should be maintained, but with different respiratory mechanics from the supine position, requiring adjustment of ventilator parameters. Electrical Impedance Tomography (EIT) technology can be used for bedside monitoring of mechanically ventilated patients, providing real-time feedback on the patient's ventilation status and having great potential for clinical applications. Investigators believes that EIT monitoring during prone position ventilation in ARDS patients can individualize lung-protective ventilation strategies, minimize alveolar overdistension and collapse, improve the weaning success rate of invasive ventilation, and ultimately improve patient prognosis.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age ≥ 18 years old;

• Meets the diagnostic criteria for ARDS according to the 2012 Berlin definition;

• Intubation with invasive mechanical ventilation time \< 36 hours;

• PaO2/FiO2 \< 150mmHg.

Locations
Other Locations
China
Beijing Chao-Yang Hospital
RECRUITING
Beijing
Contact Information
Primary
Yu Zhao, Dr.
xuanben1985@163.com
+8618601342030
Time Frame
Start Date: 2023-05-01
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 60
Treatments
Experimental: EIT guided group
During prone ventilation, the PEEP level is adjusted based on EIT monitoring.
Other: Lung protective ventilation group
Lung-protective ventilation strategy during prone positioning that continues the supine position.
Sponsors
Leads: Beijing Chao Yang Hospital

This content was sourced from clinicaltrials.gov